Immune reconstitution inflammatory syndrome manifesting as development of multiple autoimmune disorders and skin cancer progression
Identifieur interne : 001553 ( Main/Exploration ); précédent : 001552; suivant : 001554Immune reconstitution inflammatory syndrome manifesting as development of multiple autoimmune disorders and skin cancer progression
Auteurs : D. S. A. Mcleod ; M. L. Woods ; D. A. Kandiah [Australie]Source :
- Internal Medicine Journal [ 1444-0903 ] ; 2011-09.
English descriptors
- Teeft :
- Active antiretroviral, Active antiretroviral therapy, American rheumatism association, Antiretroviral, Antiretroviral therapy, Antiretroviral therapy commencement, Autoantibody, Autoimmune, Autoimmune disorders, Brief communication, Carcinoma, Clin, Clin endocrinol metab, Hrpt2 gene, Human virus, Human virus infection, Hypothyroidism, Immune, Immune reconstitution, Immune reconstitution syndrome, Immune restoration, Internal medicine, Iris, Likely pathogenesis, Literature review, Malignancy, Medicine journal, Normal range, Other thyroid autoantibodies, Parathyroid, Parathyroid cancer, Parathyroid carcinoma, Previous thyroid function tests, Reconstitution, Reconstitution syndrome, Rheumatoid arthritis, Rheumatologic disease, Royal australasian college, Royal brisbane, Skin malignancy, Strong family history, Syndrome, Systemic lupus erythematosus, Thyroid disease, Trab.
Abstract
We report the case of a 56‐year‐old man with the rare autoimmune pathologies of alternating hypothyroidism and hyperthyroidism due to thyroid‐stimulating hormone receptor antibodies, and rheumatoid arthritis as manifestations of a human immunodeficiency virus‐related immune reconstitution inflammatory syndrome. The patient also developed overt progression of a pre‐existing skin malignancy that may also be related. This case highlights immune reconstitution syndrome as an important differential diagnosis following antiretroviral therapy commencement, and that a high index of suspicion should be maintained for this rare but important cluster of conditions. Furthermore, the patient's genetic predisposition to autoimmunity provides helpful insights into the pathogenesis of these disorders.
Url:
DOI: 10.1111/j.1445-5994.2011.02546.x
Affiliations:
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The patient also developed overt progression of a pre‐existing skin malignancy that may also be related. This case highlights immune reconstitution syndrome as an important differential diagnosis following antiretroviral therapy commencement, and that a high index of suspicion should be maintained for this rare but important cluster of conditions. Furthermore, the patient's genetic predisposition to autoimmunity provides helpful insights into the pathogenesis of these disorders.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Mcleod, D S A" sort="Mcleod, D S A" uniqKey="Mcleod D" first="D. S. A." last="Mcleod">D. S. A. Mcleod</name><name sortKey="Woods, M L" sort="Woods, M L" uniqKey="Woods M" first="M. L." last="Woods">M. L. Woods</name></noCountry><country name="Australie"><noRegion><name sortKey="Kandiah, D A" sort="Kandiah, D A" uniqKey="Kandiah D" first="D. A." last="Kandiah">D. A. 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